HPV INFORMATION CENTRE

M1. HPV prevalence estimates - Women with normal cervical cytology - Top 10 HPV oncogenic types

HPV-related statistics: Women with normal cervical cytology, HPV type distribution top 10 HPV oncogenic types
	HPV type	N tested	HPV prevalence	95% confidence interval
Oceania	16	2997	5.9	(5.1-6.8)
	51	2997	3.6	(3.0-4.3)
	52	2997	2.5	(2.0-3.2)
	18	2997	2.4	(1.9-3.0)
	31	2997	2.2	(1.7-2.8)
	39	2997	2.1	(1.6-2.7)
	59	2997	1.8	(1.4-2.3)
	56	2997	1.7	(1.3-2.2)
	58	2997	1.5	(1.2-2.0)
	45	2997	1.2	(0.9-1.7)
Europe	16	180090	2.8	(2.7-2.8)
	31	164983	1.5	(1.4-1.6)
	51	154244	1.3	(1.2-1.4)
	52	153700	1.2	(1.1-1.2)
	18	178318	1.0	(0.9-1.0)
	39	152061	0.9	(0.8-0.9)
	56	153487	0.8	(0.8-0.9)
	59	150513	0.7	(0.6-0.7)
	58	155224	0.7	(0.6-0.7)
	45	155359	0.7	(0.7-0.8)
Asia	16	142676	2.3	(2.2-2.4)
	52	119710	2.0	(1.9-2.0)
	58	127203	1.3	(1.2-1.3)
	18	134981	1.1	(1.0-1.1)
	33	124689	0.7	(0.7-0.8)
	56	119318	0.6	(0.6-0.7)
	51	114924	0.6	(0.6-0.7)
	39	114047	0.6	(0.6-0.7)
	31	124291	0.6	(0.6-0.6)
	45	116818	0.4	(0.4-0.4)
Americas	16	105042	3.3	(3.2-3.4)
	51	96789	1.3	(1.2-1.4)
	31	101222	1.3	(1.2-1.3)
	52	99941	1.2	(1.2-1.3)
	18	104589	1.2	(1.1-1.3)
	59	100053	1.1	(1.0-1.1)
	39	99690	1.1	(1.0-1.2)
	58	99215	1.0	(1.0-1.1)
	56	99878	0.8	(0.8-0.9)
	45	100495	0.8	(0.8-0.9)
Africa	16	19726	2.4	(2.2-2.6)
	58	18384	1.7	(1.5-1.9)
	52	18384	1.7	(1.6-1.9)
	35	19324	1.7	(1.5-1.9)
	18	19726	1.4	(1.2-1.5)
	45	19324	1.3	(1.2-1.5)
	51	18288	1.1	(1.0-1.3)
	31	19420	1.1	(0.9-1.2)
	56	18288	0.9	(0.7-1.0)
	33	19420	0.9	(0.8-1.0)

Data updated on 30 Nov 2014
The samples for HPV testing come from cervical specimens (fresh/fixed biopsies or exfoliated cells)
References:
Europe
Agarossi A, J Med Virol 2009; 81: 529 \| Agorastos T, Eur J Cancer Prev 2004; 13: 145 \| Alexandrova YN, Cancer Lett 1999; 145: 43 \| Anderson L, J Med Virol 2013; 85: 295 \| Arbyn M, Cancer Epidemiol Biomarkers Prev 2009; 18: 321 \| Argyri E, BMC Infect Dis 2013; 13: 53 \| Astori G, Virus Res 1997; 50: 57 \| Baay MF, Eur J Cancer 2005; 41: 2704 \| Baay MF, Eur J Gynaecol Oncol 2001; 22: 204 \| Bardin A, Eur J Cancer 2008; 44: 557 \| Baudu A, J Epidemiol Glob Health 2014; 4: 35 \| Beby-Defaux A, J Med Virol 2004; 73: 262 \| Bonde J, BMC Infect Dis 2014; 14: 413 \| Bulkmans NW, Br J Cancer 2007; 96: 1419 \| Casalegno JS, Int J Gynaecol Obstet 2011; 114: 116 \| Castellsagué X, J Med Virol 2012; 84: 947 \| Centurioni MG, BMC Infect Dis 2005; 5: 77 \| Cuschieri KS, J Clin Pathol 2004; 57: 68 \| Cuzick J, Br J Cancer 1999; 81: 554 \| Cuzick J, Lancet 1995; 345: 1533 \| de Jonge M, Acta Cytol 2013; 57: 591 \| de Sanjose S, Sex Transm Dis 2003; 30: 788 \| Depuydt CE, Br J Cancer 2003; 88: 560 \| Dillner J, BMJ 2008; 337: a1754 \| Giorgi Rossi P, Infect Agents Cancer 2011; 6: 2 \| Gjøoen K, APMIS 1996; 104: 68 \| González C, Sex Transm Infect 2006; 82: 260 \| Grahovac M, Coll Antropol 2007; 31 Suppl 2: 73 \| Grainge MJ, Emerging Infect Dis 2005; 11: 1680 \| Gudleviciene Z, Medicina (Kaunas) 2005; 41: 910 \| Heard I, PLoS ONE 2013; 8: e79372 \| Hibbitts S, Br J Cancer 2006; 95: 226 \| Hibbitts S, J Clin Virol 2014; 59: 109 \| Iftner T, J Med Virol 2010; 82: 1928 \| Jacobs MV, Int J Cancer 2000; 87: 221 \| Keegan H, Br J Biomed Sci 2007; 64: 18 \| Kjaer SK, BMJ 2002; 325: 572 \| Kjaer SK, Int J Cancer 2008; 123: 1864 \| Kjellberg L, Am J Obstet Gynecol 1998; 179: 1497 \| Klug SJ, J Med Virol 2007; 79: 616 \| Komarova 2010: reported in De Vuyst H, Vaccine 2013; 31 Suppl 5: F32 \| Moga MA, Asian Pac J Cancer Prev 2014; 15: 6887 \| Molden T, Cancer Epidemiol Biomarkers Prev 2005; 14: 367 \| Monsonego J, Gynecol Obstet Fertil 2013; 41: 305 \| Muñoz N, Sex Transm Dis 1996; 23: 504 \| Naucler P, N Engl J Med 2007; 357: 1589 \| Nielsen A, Sex Transm Dis 2008; 35: 276 \| Nielsen A, Sex Transm Infect 2012; 88: 627 \| Panatto D, BMC Infect Dis 2013; 13: 575 \| Pannier-Stockman C, J Clin Virol 2008; 42: 353 \| Panotopoulou E, J Med Virol 2007; 79: 1898 \| Pista A, Clin Microbiol Infect 2011; 17: 941 \| Rogovskaya SI, Vaccine 2013; 31 Suppl 7: H46 \| Ronco G, Eur J Cancer 2005; 41: 297 \| Rozendaal L, J Clin Pathol 2000; 53: 606 \| Sammarco ML, Eur J Obstet Gynecol Reprod Biol 2013; 168: 222 \| Sargent A, Br J Cancer 2008; 98: 1704 \| Schmitt M, Int J Cancer 2013; 132: 2395 \| Shipitsyna E, Cancer Epidemiol 2011; 35: 160 \| Simanaviciene V, J Med Virol 2014 \| Svare EI, Eur J Cancer 1998; 34: 1230 \| Tachezy R, PLoS ONE 2013; 8: e79156 \| Tenti P, J Infect Dis 1997; 176: 277 \| Tornesello ML, J Gen Virol 2008; 89: 1380 \| Tornesello ML, J Med Virol 2006; 78: 1663 \| Tsiodras S, BMC Cancer 2010; 10: 53 \| Tsiodras S, Clin Microbiol Infect 2011; 17: 1185 \| Ucakar V, J Med Virol 2014; 86: 1772 \| Ucakar V, Vaccine 2012; 30: 116 \| Vaucel E, Arch Gynecol Obstet 2011; 284: 989 \| Weyn C, Cancer Epidemiol 2013; 37: 457 \| Ylitalo N, Cancer Res 2000; 60: 6027 \| Zielinski GD, Br J Cancer 2001; 85: 398
Africa
Alhamany Z, J Infect Dev Ctries 2010; 4: 732 \| Allan B, J Clin Microbiol 2008; 46: 740 \| Amrani M, J Clin Virol 2003; 27: 286 \| Astori G, Intervirology 1999; 42: 221 \| Castellsagué X, Lancet 2001; 358: 1429 \| Chaouki N, Int J Cancer 1998; 75: 546 \| Dartell MA, Int J Cancer 2014; 135: 896 \| De Vuyst H, Cancer Causes Control 2010; 21: 2309 \| De Vuyst H, Sex Transm Dis 2003; 30: 137 \| Gage JC, Int J Cancer 2012; 130: 2111 \| Hammouda D, Int J Cancer 2005; 113: 483 \| Hammouda D, Int J Cancer 2011; 128: 2224 \| Hassen E, Infection 2003; 31: 143 \| Jones HE, J Clin Microbiol 2007; 45: 1679 \| Keita N, Br J Cancer 2009; 101: 202 \| McDonald AC, PLoS ONE 2012; 7: e44332 \| Odida M, Infect Agents Cancer 2011; 6: 8 \| Piras F, Virol J 2011; 8: 514 \| Thomas JO, Br J Cancer 2004; 90: 638 \| Watson-Jones D, Sex Transm Infect 2013; 89: 358 \| Xi LF, Int J Cancer 2003; 103: 803
Americas
Abba MC, Rev Argent Microbiol 2003; 35: 74 \| Augusto EF, Rev Lat Am Enfermagem 2014; 22: 100 \| Badano I, Rev Argent Microbiol 2011; 43: 263 \| Berois N, J Med Virol 2014; 86: 647 \| Carrillo-García A, Gynecol Oncol 2014; 134: 534 \| Cassel AP, Genet Mol Biol 2014; 37: 360 \| Cathro HP, Hum Pathol 2009; 40: 942 \| Chaturvedi AK, J Med Virol 2005; 75: 105 \| Chouhy D, J Med Virol 2013; 85: 655 \| Cibas ES, Gynecol Oncol 2007; 104: 702 \| da Silva MC, Arch Gynecol Obstet 2012; 286: 1015 \| de Abreu AL, Am J Trop Med Hyg 2012; 87: 1149 \| Demers AA, Chronic Dis Inj Can 2012; 32: 177 \| Dunne EF, Cancer Causes Control 2013; 24: 403 \| Evans MF, Cancer 2006; 106: 1054 \| Fernandes J, Ann Med Health Sci Res 2013; 3: 504 \| Ferreccio C, Cancer Epidemiol Biomarkers Prev 2004; 13: 2271 \| Ferrera A, Int J Cancer 1999; 82: 799 \| García PJ, Bull World Health Organ 2004; 82: 483 \| Girianelli VR, Rev Bras Ginecol Obstet 2010; 32: 39 \| Giuliano AR, Cancer Epidemiol Biomarkers Prev 2001; 10: 1129 \| Giuliano AR, Int J STD AIDS 2005; 16: 247 \| Goodman MT, Cancer Res 2008; 68: 8813 \| Hernandez BY, Nutr Cancer 2004; 49: 109 \| Herrero R, J Infect Dis 2005; 191: 1796 \| Illades-Aguiar B, Cancer Detect Prev 2009; 32: 300 \| Illades-Aguiar B, Gynecol Oncol 2010; 117: 291 \| Insinga RP, Cancer Epidemiol Biomarkers Prev 2007; 16: 709 \| Jiang Y, Infect Agents Cancer 2013; 8: 25 \| Lazcano-Ponce E, Int J Cancer 2001; 91: 412 \| Lewis-Bell K, Rev Panam Salud Publica 2013; 33: 159 \| Lorenzato F, Int J Gynecol Cancer 2000; 10: 143 \| López Rivera MG, Infect Dis Obstet Gynecol 2012; 2012: 384758 \| Martorell M, Genet Mol Res 2012; 11: 2099 \| Matos E, Sex Transm Dis 2003; 30: 593 \| Mendoza LP, J Med Virol 2011; 83: 1351 \| Miranda PM, Genet Mol Res 2012; 11: 1752 \| Molano M, Br J Cancer 2002; 87: 324 \| Monroy OL, J Clin Virol 2010; 47: 43 \| Moore RA, Cancer Causes Control 2009; 20: 1387 \| Moscicki AB, JAMA 2001; 285: 2995 \| Muñoz N, Sex Transm Dis 1996; 23: 504 \| Noronha VL, DST J Bras Doenças Sex Transm 2005; 17: 49 \| Piña-Sánchez P, Int J Gynecol Cancer 2006; 16: 1041 \| Ragin CC, Biomarkers 2007; 12: 510 \| Ramas V, J Med Virol 2013; 85: 845 \| Rocha DA, Infect Dis Obstet Gynecol 2013; 2013: 514859 \| Rojo Contreras W, Ginecol Obstet Mex 2008; 76: 9 \| Rolón PA, Int J Cancer 2000; 85: 486 \| Santos C, Br J Cancer 2001; 85: 966 \| Schiffman M, Cancer Epidemiol Biomarkers Prev 2011; 20: 1398 \| Soto Y, J Low Genit Tract Dis 2014; 18: 210 \| Svare EI, Eur J Cancer 1998; 34: 1230 \| Swan DC, J Clin Microbiol 1999; 37: 1030 \| Sánchez-Anguiano LF, BMC Infect Dis 2006; 6: 27 \| Tamegão-Lopes BP, Infect Agents Cancer 2014; 9: 25 \| Tábora N, Am J Trop Med Hyg 2005; 73: 50 \| Vallès X, Int J Cancer 2009; 125: 1161 \| Velázquez-Márquez N, Braz J Microbiol 2010; 41: 749 \| Wheeler CM, Int J Cancer 2013; 132: 198 \| Wideroff L, Nutr Cancer 1998; 30: 130
Oceania
Aruhuri B, Cancer Prev Res (Phila) 2012; 5: 746 \| Tabrizi SN, J Clin Virol 2014; 60: 250
Asia
Aggarwal R, Indian J Cancer 2006; 43: 110 \| Al-Awadhi R, J Med Virol 2011; 83: 453 \| Alibegashvili T, Cancer Epidemiol 2011; 35: 465 \| Altun 2011: reported in Vaccarella S, Vaccine 2013; 31 Suppl 6: G32 \| An HJ, Cancer 2003; 97: 1672 \| Arora R, Eur J Obstet Gynecol Reprod Biol 2005; 121: 104 \| Asato T, J Infect Dis 2004; 189: 1829 \| Bayram A, J Med Virol 2011; 83: 1997 \| Bhatla N, Int J Gynecol Pathol 2008; 27: 426 \| Bian ML, Exp Ther Med 2013; 6: 1332 \| Chaiwongkot A, Asian Pac J Cancer Prev 2007; 8: 279 \| Chen HC, Int J Cancer 2011; 128: 1192 \| Chichareon S, J Natl Cancer Inst 1998; 90: 50 \| Cho NH, Am J Obstet Gynecol 2003; 188: 56 \| Chopjitt P, Int J Infect Dis 2009; 13: 212 \| Dai M, Br J Cancer 2006; 95: 96 \| de Boer MA, Int J Gynecol Cancer 2006; 16: 1809 \| Demir ET, J Med Virol 2012; 84: 1242 \| Ding X, J Med Virol 2014; 86: 1937 \| Dondog B, Cancer Epidemiol Biomarkers Prev 2008; 17: 1731 \| Dursun P, BMC Infect Dis 2009; 9: 191 \| Dutta S, Int J Gynecol Pathol 2012; 31: 178 \| Franceschi S, Br J Cancer 2005; 92: 601 \| Gupta S, Cytopathology 2009; 20: 249 \| Hajjaj AA, Saudi Med J 2006; 27: 487 \| Huang YK, Br J Cancer 2008; 98: 863 \| Hwang HS, Cancer Epidemiol Biomarkers Prev 2004; 13: 2153 \| Inoue M, Int J Gynecol Cancer 2006; 16: 1007 \| Jin Q, Chin Med J 2010; 123: 2004 \| Johnson DC, PLoS ONE 2014; 9: e101255 \| Kasap B, Eur J Obstet Gynecol Reprod Biol 2011; 159: 168 \| Kerkar SC, Sex Reprod Healthc 2011; 2: 7 \| Khodakarami N, Int J Cancer 2012; 131: E156 \| Kim J, Int J Gynecol Cancer 2012; 22: 1570 \| Kim MJ, Obstet Gynecol Sci 2013; 56: 110 \| Konno R, Cancer Sci 2011; 102: 877 \| Lai CH, Epidemiol Infect 2012; 140: 466 \| Laikangbam P, Int J Gynecol Cancer 2007; 17: 107 \| Laowahutanont P, Asian Pac J Cancer Prev 2014; 15: 5879 \| Lee HP, J Med Virol 2011; 83: 471 \| Lee SA, Cancer Lett 2003; 198: 187 \| Li H, Eur J Obstet Gynecol Reprod Biol 2013; 170: 202 \| Li LK, Br J Cancer 2006; 95: 1593 \| Lin H, Gynecol Oncol 2005; 96: 84 \| Maehama T, Infect Dis Obstet Gynecol 2005; 13: 77 \| Mai RQ, Asian Pac J Cancer Prev 2014; 15: 4945 \| Moradi A, Iran J Cancer Prev 2011; 3: 135 \| Mroueh AM, Eur J Gynaecol Oncol 2002; 23: 429 \| Natphopsuk S, Asian Pac J Cancer Prev 2013; 14: 6961 \| Ngelangel C, J Natl Cancer Inst 1998; 90: 43 \| Nishiwaki M, J Clin Microbiol 2008; 46: 1161 \| Oh YL, Cytopathology 2001; 12: 75 \| Onuki M, Cancer Sci 2009; 100: 1312 \| Othman N, Asian Pac J Cancer Prev 2014; 15: 2245 \| Ozalp SS, J Turk Ger Gynecol Assoc 2012; 13: 8 \| Pham TH, Int J Cancer 2003; 104: 213 \| Raza SA, Br J Cancer 2010; 102: 1657 \| Safaei A, Indian J Pathol Microbiol 2010; 53: 681 \| Sasagawa T, Cancer Epidemiol Biomarkers Prev 2001; 10: 45 \| Sasagawa T, Jpn J Cancer Res 1997; 88: 376 \| Settheetham-Ishida W, Microbiol Immunol 2005; 49: 417 \| Sherpa AT, Cancer Causes Control 2010; 21: 323 \| Shin HR, Int J Cancer 2003; 103: 413 \| Singh A, Int J Gynecol Cancer 2009; 19: 1642 \| Siritantikorn S, Southeast Asian J Trop Med Public Health 1997; 28: 707 \| Sriamporn S, Int J Gynecol Cancer 2006; 16: 266 \| Sukvirach S, J Infect Dis 2003; 187: 1246 \| Sun ZR, Int J Gynaecol Obstet 2010; 109: 105 \| Suwannarurk K, Cancer Epidemiol 2009; 33: 56 \| Takehara K, Patholog Res Int 2011; 2011: 246936 \| Tezcan S, Asian Pac J Cancer Prev 2014; 15: 3997 \| Tsai HT, Cancer Epidemiol Biomarkers Prev 2005; 14: 2544 \| Tshomo U, BMC Infect Dis 2014; 14: 408 \| Vinodhini K, Int J Gynaecol Obstet 2012; 119: 253 \| Wei H, Int J Gynaecol Obstet 2014; 126: 28 \| Wu D, Eur J Obstet Gynecol Reprod Biol 2010; 151: 86 \| Wu EQ, Cancer Causes Control 2013; 24: 795 \| Wu RF, Int J Cancer 2007; 121: 1306 \| Yoshikawa H, Br J Cancer 1999; 80: 621 \| Yuan X, Arch Gynecol Obstet 2011; 283: 1385 \| Zhao FH, Int J Cancer 2014; 135: 2604 \| Zhao R, Br J Cancer 2009; 101: 1635
Based on systematic reviews and meta-analysis performed by ICO. The ICO HPV Information Centre has updated data until November 2014. Reference publications: 1) Bruni L, J Infect Dis 2010; 202: 1789. 2) De Sanjosé S, Lancet Infect Dis 2007; 7: 453

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